Effects of diuretics on heart and kidney health in veterans with chronic kidney disease
Official title: Association of diuretics with change in extracellular volume, natriuretic peptides, symptoms, and cardiovascular outcomes in CKD
Funded at Michael E Debakey VA Medical Center · NIH-11043351 · Data updated 2026-11-12
This study is looking at how diuretics, which help get rid of extra fluid, impact heart and kidney health in veterans with chronic kidney disease, to find better ways to improve their overall well-being.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Michael E Debakey VA Medical Center NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | January 1, 2022 |
| Project end | December 31, 2026 |
| Funding year | 2025 |
| NIH project number | 5IK2CX002368-04 |
| Project ID | NIH-11043351 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are veterans aged 21 and older who have been diagnosed with chronic kidney disease.
✕Less likely to help
Patients who do not have chronic kidney disease or are not veterans may not receive any benefit from this research.
What this research studies
This research investigates how diuretics, medications that help remove excess fluid from the body, affect heart and kidney health in veterans suffering from chronic kidney disease (CKD). The study will measure changes in extracellular volume, levels of specific heart-related peptides, and various cardiovascular outcomes. By using advanced techniques like bioimpedance spectroscopy, researchers aim to understand the relationship between diuretic use and patient symptoms, as well as overall cardiovascular function. The research is designed to improve treatment strategies for veterans with CKD, ultimately enhancing their quality of life.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment protocols for veterans with CKD, potentially enhancing their cardiovascular health and overall well-being.
How similar studies have gone: Previous research has shown promising results in understanding the effects of diuretics on cardiovascular health, making this study a continuation of established findings.
Where this research is happening
-
Michael E Debakey VA Medical Center
Houston, United States Active
Researchers
- Principal investigator: Gregg, Lucile Parker — Michael E Debakey VA Medical Center
- Study coordinator: Gregg, Lucile Parker
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.