Effects of diet and exercise on cognitive health in older adults
Official title: Age-related Cognitive Changes: Effects of Combined Flavonoid Intake and Physical Exertion Mediated by the Gut Microbiome
Funded at North Carolina State University Raleigh · NIH-11176254 · Data updated 2026-11-12
This study is looking at how eating foods high in flavonoids and staying active can help improve brain health in older adults over 65, while also checking how our gut health plays a role in this process.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | North Carolina State University Raleigh NIH-funded |
| Lab location | 1 site (Raleigh, United States) |
| Project start | September 1, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $536,533 |
| NIH project number | 5R01AG084660-02 |
| Project ID | NIH-11176254 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 65 and older who are interested in improving their cognitive health through diet and exercise.
✕Less likely to help
Patients who are not 65 years or older or those with severe cognitive impairment may not benefit from this research.
What this research studies
This research investigates how a diet rich in flavonoids combined with regular physical activity can influence cognitive changes in older adults, particularly those over 65. It focuses on the role of the gut microbiome in mediating these effects, as previous studies suggest that both diet and exercise can enhance cognitive performance and reduce the risk of dementia. Participants may engage in dietary modifications and exercise routines while researchers monitor changes in cognitive function and gut health. The study aims to establish a clear link between these lifestyle factors and cognitive health outcomes.
Why it matters
Potential benefit: If successful, this research could lead to effective dietary and exercise recommendations that help maintain cognitive function and reduce the risk of dementia in older adults.
How similar studies have gone: Previous research has shown promising results in the cognitive benefits of flavonoid-rich diets and physical activity, suggesting that this approach may be effective.
Where this research is happening
-
North Carolina State University Raleigh
Raleigh, United States Active
Researchers
- Principal investigator: Lila, Mary Ann Ann — North Carolina State University Raleigh
- Study coordinator: Lila, Mary Ann Ann
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.