Effects of diabetes medications during pregnancy on mothers and children
Official title: Comparing the effects of pharmacological treatment for gestational diabetes on long-term maternal and child health outcomes
Funded at Kaiser Foundation Research Institute · NIH-11002709 · Data updated 2026-11-12
This study looks at how different medications for gestational diabetes, like metformin, glyburide, and insulin, impact the long-term health of moms and their kids, helping to find the best treatment options for a healthier future.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Kaiser Foundation Research Institute NIH-funded |
| Lab location | 1 site (Oakland, UNITED STATES) |
| Project start | December 20, 2023 |
| Project end | November 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $605,082 |
| NIH project number | 5R01DK138135-02 |
| Project ID | NIH-11002709 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are pregnant individuals diagnosed with gestational diabetes who required pharmacological treatment.
✕Less likely to help
Patients who do not have gestational diabetes or those who managed their condition solely through diet will not benefit from this research.
What this research studies
This research investigates how different medications used to treat gestational diabetes affect the long-term health of mothers and their children. By analyzing data from over 44,000 patients at Kaiser Permanente, the study will track health outcomes for up to 18 years after treatment. It focuses on those who required medication during pregnancy and compares the effects of metformin, glyburide, and insulin. The goal is to understand the best treatment options for improving health outcomes for both mothers and their children.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for gestational diabetes, enhancing the long-term health of mothers and their children.
How similar studies have gone: Previous research has shown that pharmacological treatments can have significant effects on health outcomes, but this specific approach to comparing long-term effects is novel.
Where this research is happening
-
Kaiser Foundation Research Institute
Oakland, United States Active
Researchers
- Principal investigator: Hedderson, Monique Marie — Kaiser Foundation Research Institute
- Study coordinator: Hedderson, Monique Marie
Related research
Other NIH-funded projects on the same topics.
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Digital twins of the hypothalamus, placenta, and gut to help manage gestational diabetes
A study using computer-based models of a pregnant person’s brain, placenta, and gut to better understand how gestational diabetes develops and how to tailor treatments.
-
IGF factors and binding proteins in gestational diabetes and fetal growth
A study in pregnant people looks at how insulin-like growth factors and their binding proteins affect gestational diabetes and how a baby grows.
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STRONG group prenatal care to reduce gestational diabetes in American Samoa
A Yale-led program tests a group prenatal care approach to lower gestational diabetes among pregnant Pacific Islander women in American Samoa.
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Pancreatic beta cells, oxidative stress, and gestational diabetes
A study is exploring how oxidative stress and changes in pancreatic beta cells during pregnancy may contribute to gestational diabetes and future diabetes risk for both mother and baby.
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NDPP-MAP: A tailored online-hybrid program to reduce long-term health risks after pregnancy with gestational diabetes
A patient-friendly program adapts a proven diabetes prevention approach to help women who had gestational diabetes lower their risk of type 2 diabetes and heart problems.
-
In Vivo Look at Placental Blood Flow in Gestational Diabetes
A non-invasive MRI study in pregnant people with gestational diabetes and those without will map how placental blood vessels work and relate to baby outcomes.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.