Effects of CPAP on lung development in premature infants
Official title: Adverse Effects of Neonatal CPAP on Lung Development
Funded at Case Western Reserve University · NIH-11061946 · Data updated 2026-11-12
This study is looking at how using CPAP, a common breathing treatment for premature babies, might impact their lung health as they grow, especially in relation to asthma and breathing issues later in childhood.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | June 1, 2025 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $740,196 |
| NIH project number | 1R01HL177837-01 |
| Project ID | NIH-11061946 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are preterm infants who require respiratory support, particularly those treated with CPAP.
✕Less likely to help
Patients who are not preterm or do not require respiratory support may not benefit from this research.
What this research studies
This research investigates how continuous positive airway pressure (CPAP), a common treatment for preterm infants with respiratory distress, affects lung development. The study aims to understand the long-term consequences of CPAP on respiratory health, particularly focusing on airway hyperreactivity and asthma in children who were treated with this method. Using a novel mouse model, researchers will explore the mechanisms by which CPAP may lead to adverse respiratory outcomes, providing insights that could improve care practices in neonatal intensive care units.
Why it matters
Potential benefit: If successful, this research could lead to improved respiratory care practices for preterm infants, potentially reducing the incidence of asthma and other respiratory issues later in life.
How similar studies have gone: While the effects of other respiratory support methods have been studied, the specific impact of CPAP on lung development is less understood, making this research a novel exploration.
Where this research is happening
-
Case Western Reserve University
Cleveland, United States Active
Researchers
- Principal investigator: Macfarlane, Peter — Case Western Reserve University
- Study coordinator: Macfarlane, Peter
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.