Effects of CPAP on lung development in premature infants
Adverse Effects of Neonatal CPAP on Lung Development
['FUNDING_R01'] · CASE WESTERN RESERVE UNIVERSITY · NIH-11061946
This study is looking at how using CPAP, a common breathing treatment for premature babies, might impact their lung health as they grow, especially in relation to asthma and breathing issues later in childhood.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CASE WESTERN RESERVE UNIVERSITY (nih funded) |
| Locations | 1 site (CLEVELAND, UNITED STATES) |
| Trial ID | NIH-11061946 on ClinicalTrials.gov |
What this research studies
This research investigates how continuous positive airway pressure (CPAP), a common treatment for preterm infants with respiratory distress, affects lung development. The study aims to understand the long-term consequences of CPAP on respiratory health, particularly focusing on airway hyperreactivity and asthma in children who were treated with this method. Using a novel mouse model, researchers will explore the mechanisms by which CPAP may lead to adverse respiratory outcomes, providing insights that could improve care practices in neonatal intensive care units.
Who could benefit from this research
Good fit: Ideal candidates for this research are preterm infants who require respiratory support, particularly those treated with CPAP.
Not a fit: Patients who are not preterm or do not require respiratory support may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved respiratory care practices for preterm infants, potentially reducing the incidence of asthma and other respiratory issues later in life.
How similar studies have performed: While the effects of other respiratory support methods have been studied, the specific impact of CPAP on lung development is less understood, making this research a novel exploration.
Where this research is happening
CLEVELAND, UNITED STATES
- CASE WESTERN RESERVE UNIVERSITY — CLEVELAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MACFARLANE, PETER — CASE WESTERN RESERVE UNIVERSITY
- Study coordinator: MACFARLANE, PETER
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.