Effects of continuous flow heart devices on brain circulation
Neurovascular Consequences of Non-Pulsatile Flow from Left Ventricular Assist Devices
This study looks at how a special heart pump called a continuous flow left ventricular assist device (CF-LVAD) affects blood flow in the brain for patients with advanced heart failure, helping us learn more about possible risks like strokes and bleeding after the device is put in.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11001183 on NIH RePORTER |
What this research studies
This research investigates how continuous flow left ventricular assist devices (CF-LVAD) affect blood flow in the brain. It focuses on patients with advanced heart failure who rely on these devices for support. By using transcranial Doppler ultrasound, the study will measure changes in cerebral circulation before and after the implantation of CF-LVAD. The goal is to understand the potential complications, such as strokes and bleeding, that may arise from non-pulsatile blood flow.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with end-stage heart failure who are receiving or are candidates for continuous flow left ventricular assist devices.
Not a fit: Patients who are not candidates for left ventricular assist devices or those with other unrelated neurological conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved management and outcomes for patients using heart assist devices.
How similar studies have performed: While the effects of CF-LVAD on cerebral circulation have not been extensively studied, related research on blood flow dynamics in other contexts has shown promising results.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Willey, Joshua Zebadiah — Columbia University Health Sciences
- Study coordinator: Willey, Joshua Zebadiah
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.