Effects of chemical exposure before and during pregnancy on fertility and metabolic health across generations
Transgenerational consequences of pre-conceptional and in utero exposure to real-life chemical mixtures on fertility and metabolic health
This study is looking at how being exposed to certain environmental chemicals before and during pregnancy might affect fertility and health in future generations, using pregnant sheep to help us understand what this could mean for humans.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-10745710 on NIH RePORTER |
What this research studies
This research investigates how exposure to a mixture of environmental chemicals before and during pregnancy can affect fertility and metabolic health in future generations. Using a unique animal model, pregnant sheep will be exposed to biosolids, which mimic the chemical exposure humans face. The study aims to understand the long-term metabolic changes in the offspring across three generations, providing insights into how these exposures may influence health outcomes in humans. By examining these effects, the research seeks to uncover potential transgenerational impacts of environmental chemicals on reproductive and metabolic health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are planning to conceive or are currently pregnant, particularly those concerned about environmental exposures.
Not a fit: Patients who are not planning to conceive or are beyond reproductive age may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and prevention strategies for fertility issues and metabolic disorders in humans.
How similar studies have performed: While there is existing research on single chemical exposures, this study's approach of examining real-life chemical mixtures and their transgenerational effects is relatively novel.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Padmanabhan, Vasantha — University of Michigan at Ann Arbor
- Study coordinator: Padmanabhan, Vasantha
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.