Effects of cannabis use during adolescence on brain function and behavior

Impact of Cannabinoid Across the Lifespan (ICAL)

['FUNDING_OTHER'] · UNIVERSITY OF CALIFORNIA-IRVINE · NIH-10932777

This study is looking at how using cannabis as a teenager might change the way the brain works, which could affect thinking and behavior later in life, and it aims to help us understand the risks of cannabis during important growing years.

Quick facts

Phase['FUNDING_OTHER']
Study typeNih_funding
SexAll
SponsorUNIVERSITY OF CALIFORNIA-IRVINE (nih funded)
Locations1 site (IRVINE, UNITED STATES)
Trial IDNIH-10932777 on ClinicalTrials.gov

What this research studies

This research investigates how cannabis use during adolescence affects the endocannabinoid signaling system in the brain, potentially leading to long-term changes in cognition and behavior. By using a combination of molecular, synaptic, and behavioral approaches, the study aims to understand the biological mechanisms behind these changes. The research involves animal models to simulate adolescent cannabis use and assess its impacts on brain function and behavior over time. Patients may benefit from insights gained about the risks associated with cannabis use during critical developmental periods.

Who could benefit from this research

Good fit: Ideal candidates for participation or benefit from this research include adolescents and young adults who have used cannabis or are considering its use.

Not a fit: Patients who have not used cannabis or are outside the adolescent to young adult age range may not receive direct benefits from this research.

Why it matters

Potential benefit: If successful, this research could provide valuable information on the long-term effects of adolescent cannabis use, helping to inform public health policies and prevention strategies.

How similar studies have performed: Previous research has shown significant effects of adolescent cannabis use on brain development, indicating that this approach is building on established findings.

Where this research is happening

IRVINE, UNITED STATES

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.

View on NIH RePORTER →

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.