Effects of cannabis use during adolescence on addiction risk
Impact of Cannabinoid Across the Lifespan (ICAL)
This study looks at how using THC, the main ingredient in cannabis, at a young age might increase the chances of becoming addicted to stronger drugs like opioids later on, especially by examining how it affects brain development during teenage years.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project ID | NIH-11121026 on NIH RePORTER |
What this research studies
This research investigates how early exposure to THC, the active component in cannabis, affects the risk of developing addiction to harder drugs like opioids later in life. Using rodent models, the study aims to understand the biological mechanisms behind this vulnerability, particularly focusing on how THC impacts brain development during adolescence. The research examines sex differences in response to THC and its potential to influence behaviors associated with drug reward and addiction. By exploring these factors, the study seeks to provide insights into the long-term psychiatric risks associated with adolescent cannabis use.
Who could benefit from this research
Good fit: Ideal candidates for this research are adolescents aged 12-20 who have a history of cannabis use or are at risk for substance abuse.
Not a fit: Patients who are not adolescents or who have not used cannabis may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to better prevention strategies and interventions for adolescents at risk of developing substance use disorders.
How similar studies have performed: Previous research has shown significant findings regarding the impact of adolescent cannabis use on addiction risk, suggesting that this area of study is both relevant and critical.
Where this research is happening
Irvine, United States
- University of California-Irvine — Irvine, United States (Active)
Researchers
- Principal investigator: Mahler, Stephen Vincent — University of California-Irvine
- Study coordinator: Mahler, Stephen Vincent
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.