Effects of cannabis on brain development and memory in adolescents and adults

Impact of Cannabinoid Across the Lifespan (ICAL)

NIH-funded research University of California-Irvine · NIH-11121016

This study is looking at how using cannabis as a teenager might change the way your brain develops, especially when it comes to memory and learning, and it wants to find out if these effects are different for boys and girls or based on age.

Quick facts

Grant typeNIH-funded research
Study typeNIH-funded research
Funding institutionUniversity of California-Irvine NIH-funded
Lab location1 site (Irvine, United States)
Project IDNIH-11121016 on NIH RePORTER

What this research studies

This research investigates how cannabis use during adolescence affects brain development, particularly focusing on memory and learning. It examines the neurobiological mechanisms behind these effects, specifically looking at how THC exposure impacts synaptic plasticity in the brain. The study aims to understand the differences in these effects based on age and sex, and how they relate to cognitive functions. By exploring these relationships, the research seeks to provide insights into the long-term consequences of cannabis use during critical developmental periods.

Who could benefit from this research

Good fit: Ideal candidates for this research include adolescents aged 12-20 and adults over 21 who have used cannabis.

Not a fit: Patients who have never used cannabis or are not within the specified age ranges may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to better understanding and management of cognitive impairments associated with cannabis use in young people.

How similar studies have performed: Previous research has indicated that cannabis can have significant effects on brain development, suggesting that this study builds on established findings rather than exploring entirely novel territory.

Where this research is happening

Irvine, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.