Effects of cannabinoids on HIV and treatment in the brain
Inter- and Intra-cellular effects of cannabinoids, HIV and ART in the CNS
This study is looking at how cannabis compounds might help reduce inflammation and pain in the brain for people living with HIV, while also figuring out how these compounds work alongside HIV treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11084435 on NIH RePORTER |
What this research studies
This research investigates how cannabinoids interact with HIV and antiretroviral therapy (ART) within the central nervous system (CNS). It focuses on understanding the potential anti-inflammatory and immunomodulatory effects of cannabinoids, particularly in relation to neuronal disorders and pain experienced by people living with HIV. The study will explore the impact of cannabinoids on HIV infection in brain cells, including microglia and astrocytes, and aims to differentiate the therapeutic effects from the psychotropic effects of cannabis. By examining these interactions, the research seeks to provide insights into better management of co-morbid conditions associated with HIV.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals living with HIV who experience anxiety, stress, or pain and are interested in the potential benefits of cannabinoid use.
Not a fit: Patients who do not have HIV or those who do not experience co-morbid conditions related to HIV may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options for managing pain and anxiety in people living with HIV.
How similar studies have performed: Previous research has shown promising results regarding the anti-inflammatory effects of cannabinoids, suggesting potential for success in this area.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Jordan-Sciutto, Kelly L — University of Pennsylvania
- Study coordinator: Jordan-Sciutto, Kelly L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.