Effects of cannabidiol on health in older cannabis users
Official title: Cannabidiol and Older Adult Cannabis Users: A Randomized, Placebo Controlled Study
Funded at University of Colorado Denver · NIH-10912693 · Data updated 2026-11-12
This study is looking at how using cannabis, especially CBD and small amounts of THC, might help or hurt the health and thinking skills of older adults aged 65 and up, particularly those dealing with memory issues like mild cognitive impairment or Alzheimer's.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | September 1, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $446,278 |
| NIH project number | 5P50DA056408-02 |
| Project ID | NIH-10912693 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults aged 65 and over who use or are considering using cannabis for health-related reasons.
✕Less likely to help
Patients who are not cannabis users or those under 65 years of age may not receive benefits from this research.
What this research studies
This research investigates how cannabis use, particularly cannabidiol (CBD) and low doses of THC, affects the physical and cognitive health of older adults aged 65 and over. It aims to understand the potential benefits and risks associated with cannabis use in this population, especially concerning conditions like mild cognitive impairment and Alzheimer's dementia. The study will involve a randomized, placebo-controlled design to assess the impact of these substances on cognitive decline and overall health outcomes. Participants will be monitored for changes in inflammation and neurodegeneration, which are critical factors in aging.
Why it matters
Potential benefit: If successful, this research could provide insights into safe cannabis use for improving health outcomes in older adults.
How similar studies have gone: Previous studies have shown promising results regarding the neuroprotective effects of CBD and low-dose THC, suggesting potential benefits for cognitive health in older adults.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Bryan, Angela — University of Colorado Denver
- Study coordinator: Bryan, Angela
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.