Effects of calorie restriction on aging and healthspan
Legacy Effects of CALERIE, a 2-year Calorie Restriction Intervention, on Hallmarks of Healthspan and Aging
This study is looking at how a two-year calorie restriction program might help adults feel healthier and age better over the long run, by checking in on them 10 to 15 years later and comparing their health to those who didn’t follow the program.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Tufts University Boston NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11019668 on NIH RePORTER |
What this research studies
This research investigates the long-term effects of a two-year calorie restriction (CR) intervention on aging and health in adults. Participants who previously engaged in a CR program will be followed up 10 to 15 years later to assess improvements in biological aging markers, physical function, and overall quality of life. The study compares these individuals to a control group that did not undergo calorie restriction, aiming to understand how dietary changes can influence aging processes.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who participated in the original CALERIE trial.
Not a fit: Patients who did not participate in the CALERIE trial or are under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide insights into dietary strategies that promote healthier aging and improve quality of life.
How similar studies have performed: Previous studies, including the original CALERIE trial, have shown promising results regarding the effects of calorie restriction on health and aging.
Where this research is happening
Boston, United States
- Tufts University Boston — Boston, United States (Active)
Researchers
- Principal investigator: Das, Sai Krupa — Tufts University Boston
- Study coordinator: Das, Sai Krupa
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.