Effects of binge drinking on brain cell interactions
Long-term effects of binge drinking on astrocyte-synaptic interactions
['FUNDING_OTHER'] · HUNTINGTON VETERANS AFFAIRS MED CTR · NIH-10980501
This study looks at how binge drinking affects brain cells in combat veterans who may struggle with alcohol use, using rats to understand the long-term effects on thinking and memory, with the hope of finding new ways to help those dealing with alcohol-related challenges.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | HUNTINGTON VETERANS AFFAIRS MED CTR (nih funded) |
| Locations | 1 site (HUNTINGTON, UNITED STATES) |
| Trial ID | NIH-10980501 on ClinicalTrials.gov |
What this research studies
This research investigates how binge drinking affects the interactions between astrocytes and neurons in the brain, particularly focusing on combat veterans who are at higher risk for alcohol use disorders. By using a rat model, the study examines the long-term impacts of repeated binge drinking on brain structure and function, aiming to uncover the mechanisms behind cognitive impairments associated with alcohol abuse. The research involves analyzing changes in astrocyte signaling and its effects on synaptic communication, which could provide insights into potential therapeutic targets for those affected by alcohol-related cognitive decline.
Who could benefit from this research
Good fit: Ideal candidates for this research are young veterans, particularly those aged 20 to 25, who have a history of binge drinking or alcohol use disorder.
Not a fit: Patients who do not have a history of alcohol use or cognitive impairments related to alcohol are unlikely to benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for cognitive impairments related to alcohol abuse in veterans.
How similar studies have performed: Previous studies using similar models have shown significant impacts of binge drinking on brain function, indicating that this research builds on established findings.
Where this research is happening
HUNTINGTON, UNITED STATES
- HUNTINGTON VETERANS AFFAIRS MED CTR — HUNTINGTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RISHER, MARY-LOUISE — HUNTINGTON VETERANS AFFAIRS MED CTR
- Study coordinator: RISHER, MARY-LOUISE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.