Effects of azithromycin given during cesarean delivery on children's lung and gut health.
Childhood Pulmonary and Related Outcomes after Perinatal Exposure to Adjunctive Azithromycin Prophylaxis for Cesarean Delivery (C/SOAP Follow-Up Study)
This study is looking at how giving a common antibiotic called azithromycin to moms during C-sections might affect their children's lung and gut health as they grow up, comparing those kids to others who didn't get the antibiotic, to see if there are any long-term benefits or downsides.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project ID | NIH-10910978 on NIH RePORTER |
What this research studies
This research investigates the long-term effects of azithromycin, an antibiotic given to mothers during cesarean deliveries, on the lung and gastrointestinal health of their children. It compares outcomes in children who were exposed to azithromycin with those who received a placebo, focusing on potential changes in the gut microbiome and related health issues such as asthma and inflammatory bowel disease. The study aims to understand whether the benefits of reducing maternal infections outweigh any negative impacts on children's health.
Who could benefit from this research
Good fit: Ideal candidates for this research include children aged 0-11 years who were born via cesarean delivery and whose mothers received azithromycin during the procedure.
Not a fit: Patients who were not born via cesarean delivery or who did not receive azithromycin during birth may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved guidelines for antibiotic use during cesarean deliveries, potentially enhancing the long-term health of children.
How similar studies have performed: Previous studies have shown promising results regarding the benefits of azithromycin in reducing maternal infections, but the long-term effects on children's health are still being explored.
Where this research is happening
Birmingham, United States
- University of Alabama at Birmingham — Birmingham, United States (Active)
Researchers
- Principal investigator: Subramaniam, Akila — University of Alabama at Birmingham
- Study coordinator: Subramaniam, Akila
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.