Effects of antibiotics on gut bacteria and health outcomes in hospitalized Veterans
Official title: Impact of anti-anaerobic antibiotics on clinical outcomes and the microbiome in hospitalized Veterans
Funded at Veterans Health Administration · NIH-11072094 · Data updated 2026-11-12
This study is looking at how certain antibiotics used in hospitals might change the good bacteria in the gut of Veterans and whether these changes could lead to more health problems, like infections or even higher risks of death.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Veterans Health Administration NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | March 1, 2024 |
| Project end | February 28, 2029 |
| Funding year | 2025 |
| NIH project number | 5IK2CX002766-02 |
| Project ID | NIH-11072094 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are hospitalized Veterans who are being treated with anti-anaerobic antibiotics.
✕Less likely to help
Patients who are not hospitalized or those not receiving anti-anaerobic antibiotics may not benefit from this research.
What this research studies
This research investigates how the use of anti-anaerobic antibiotics affects the gut microbiome and clinical outcomes in hospitalized Veterans. It aims to determine if these antibiotics lead to harmful effects such as increased mortality and infections by analyzing data from a large cohort of patients. The study will also explore the microbiological and immunological changes that occur when gut anaerobes are depleted, using both retrospective and prospective approaches to gather comprehensive data on patient health. By examining gut bacteria and related health markers, the research seeks to provide insights into the consequences of antibiotic treatment.
Why it matters
Potential benefit: If successful, this research could lead to improved antibiotic prescribing practices and better health outcomes for hospitalized patients.
How similar studies have gone: Previous research has indicated potential risks associated with antibiotic use and microbiome alterations, suggesting that this approach could yield significant insights.
Where this research is happening
-
Veterans Health Administration
Ann Arbor, United States Active
Researchers
- Principal investigator: Chanderraj, Rishi — Veterans Health Administration
- Study coordinator: Chanderraj, Rishi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.