Effects of alcohol on brain cell communication and exosome function
Official title: Chronic alcohol effects on the biogenesis, distribution, and RNA content of astrocytic exosomes
Funded at University of California Los Angeles · NIH-10988592 · Data updated 2026-11-12
This study is looking at how drinking alcohol over a long time affects the way brain cells talk to each other, especially focusing on tiny particles called exosomes that help keep the brain healthy, to find out more about how alcohol can harm the brain and what that might mean for people dealing with related health issues.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $187,031 |
| NIH project number | 1R21AA031366-01A1 |
| Project ID | NIH-10988592 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with a history of heavy alcohol use or those experiencing brain injuries related to alcohol consumption.
✕Less likely to help
Patients who do not consume alcohol or have no history of alcohol-related brain issues may not benefit from this research.
What this research studies
This research investigates how chronic alcohol consumption affects the communication between brain cells, specifically focusing on astrocytes and neurons. It aims to understand the role of exosomes, which are small vesicles released by astrocytes, in maintaining brain health and how they may be altered by alcohol use. By analyzing the RNA content and distribution of these exosomes, the study seeks to uncover the underlying mechanisms of alcohol-induced brain damage and potential biomarkers for related conditions. Patients may benefit from insights into how alcohol affects brain function and potential new diagnostic tools.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for individuals with alcohol use disorder and related brain injuries.
How similar studies have gone: Previous research has shown promise in understanding the role of exosomes in brain health, indicating that this approach may yield valuable insights.
Where this research is happening
-
University of California Los Angeles
Los Angeles, United States Active
Researchers
- Principal investigator: Kim, Yong — University of California Los Angeles
- Study coordinator: Kim, Yong
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.