Effects of adolescent social isolation on mental health
Long-term effects of adolescent social isolation on the interactions between CRF and serotonergic systems
This study looks at how feeling lonely as a teenager can impact the brain and lead to anxiety and depression later in life, helping us understand how early experiences with friends can affect mental health as we grow up.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project ID | NIH-11002731 on NIH RePORTER |
What this research studies
This research investigates how social isolation during adolescence affects brain systems related to stress and anxiety. It focuses on understanding the neural mechanisms that link early adverse experiences, like disrupted peer interactions, to the development of anxiety and depressive disorders in adulthood. By studying specific brain regions and their connections, the research aims to uncover how these experiences influence mental health later in life. The approach includes examining the role of serotonin and corticotropin-releasing factor in these processes.
Who could benefit from this research
Good fit: Ideal candidates for this research are adolescents aged 12-20 who have experienced social isolation or disrupted peer interactions.
Not a fit: Patients who have not experienced social isolation or related adverse childhood experiences may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for anxiety and depression stemming from adolescent social isolation.
How similar studies have performed: Previous research has shown that understanding the neural mechanisms of stress and social experiences can lead to significant advancements in mental health treatment.
Where this research is happening
Indianapolis, United States
- Indiana University Indianapolis — Indianapolis, United States (Active)
Researchers
- Principal investigator: Lukkes, Jodi L — Indiana University Indianapolis
- Study coordinator: Lukkes, Jodi L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.