Effects of a specific gene disruption on dopamine function and behavior
Impact of Grin2b/GluN2B disruption on dopaminergic function and related behavior
This study is looking at how changes in a specific gene related to autism might affect brain chemicals and behaviors, using mice to help us understand more about autism and find new ways to help.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York State Psychiatric Institute Dba Research Foundation for Mental Hygiene, INC NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10989068 on NIH RePORTER |
What this research studies
This research investigates how the disruption of the GRIN2B gene, which is linked to autism spectrum disorder (ASD), affects dopamine function and related behaviors. Using genetic mouse models, the study will explore the role of NMDA-GluN2B receptors in modulating dopamine neuron activity and how this impacts behaviors associated with ASD. The researchers will employ a conditional genetic strategy to observe changes in dopamine release and behavior when GluN2B is disrupted. This approach aims to provide insights into the biological mechanisms underlying ASD and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with autism spectrum disorder, particularly those with genetic variations affecting the GRIN2B gene.
Not a fit: Patients without autism spectrum disorder or those not carrying relevant genetic variations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments targeting dopamine function in individuals with autism spectrum disorder.
How similar studies have performed: Previous research has shown promising results in understanding the role of dopamine in autism, suggesting that this approach could yield valuable insights.
Where this research is happening
New York, United States
- New York State Psychiatric Institute Dba Research Foundation for Mental Hygiene, INC — New York, United States (Active)
Researchers
- Principal investigator: Veenstra-Vanderweele, Jeremy — New York State Psychiatric Institute Dba Research Foundation for Mental Hygiene, INC
- Study coordinator: Veenstra-Vanderweele, Jeremy
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.