Effects of a medication on brain function and thinking skills in veterans with schizophrenia
GLP-1 Receptor Agonist Effects on Neuronal Function and Cognition in Veterans with Schizophrenia
This study is looking at how a medication called a GLP-1 receptor agonist might help improve thinking and brain function in veterans with schizophrenia, using special imaging to see how it affects their brain activity.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA Eastern Colorado Health Care System NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-11054481 on NIH RePORTER |
What this research studies
This research investigates how a specific medication, known as a GLP-1 receptor agonist, can improve brain function and cognitive abilities in veterans diagnosed with schizophrenia. The study focuses on understanding the relationship between brain activity, particularly in the hippocampus, and cognitive deficits that affect daily life. By using advanced imaging techniques, researchers aim to identify changes in brain function that correlate with improvements in thinking skills. The ultimate goal is to develop effective treatments that enhance cognitive performance in this population.
Who could benefit from this research
Good fit: Ideal candidates for this research are veterans diagnosed with schizophrenia who experience cognitive difficulties.
Not a fit: Patients without a diagnosis of schizophrenia or those who do not experience cognitive deficits may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve cognitive function and quality of life for veterans with schizophrenia.
How similar studies have performed: Previous research has shown promise in targeting cognitive deficits in schizophrenia, but this specific approach using GLP-1 receptor agonists is relatively novel.
Where this research is happening
Aurora, UNITED STATES
- VA Eastern Colorado Health Care System — Aurora, United States (Active)
Researchers
- Principal investigator: Tregellas, Jason R — VA Eastern Colorado Health Care System
- Study coordinator: Tregellas, Jason R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.