Effects of a medication on brain function and thinking skills in veterans with schizophrenia

Who could benefit from this research

What this research studies

This research investigates how a specific medication, known as a GLP-1 receptor agonist, can improve brain function and cognitive abilities in veterans diagnosed with schizophrenia. The study focuses on understanding the relationship between brain activity, particularly in the hippocampus, and cognitive deficits that affect daily life. By using advanced imaging techniques, researchers aim to identify changes in brain function that correlate with improvements in thinking skills. The ultimate goal is to develop effective treatments that enhance cognitive performance in this population.

Why it matters

Where this research is happening

• VA Eastern Colorado Health Care System
  Aurora, United States Active

Researchers

• Principal investigator: Tregellas, Jason R — VA Eastern Colorado Health Care System
• Study coordinator: Tregellas, Jason R

Related research

Other NIH-funded projects on the same topics.

• Home-based aerobic exercise plus online brain training to improve thinking after a first schizophrenia episode

  This program combines guided aerobic exercise with web-based cognitive training delivered by telehealth to help thinking and daily functioning for people after a first schizophrenia episode.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11306042

• Using telehealth to improve thinking skills through exercise and cognitive training for people with schizophrenia.

  This study is looking at a new way to help people who have had their first episode of schizophrenia by using online exercise and brain training to boost their thinking skills and overall well-being.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11062469

• Investigating brain stimulation effects on cognitive control in schizophrenia

  This study is looking at how a gentle brain stimulation technique called tDCS can help people with schizophrenia improve their focus and thinking skills by targeting a specific area of the brain, and it involves monitoring brain activity while participants receive this treatment.

  NIH research University of California-Irvine · Irvine, United States · NIH-10951161

• Understanding how CHR individuals process social cues through sight and sound

  This project studies how people at clinical high risk for schizophrenia interpret social cues from movies and spoken stories, and how their brain activity relates to these abilities.

  NIH research New York State Psychiatric Institute Dba Research Foundation for Mental Hygiene, INC · New York, United States · NIH-10687873

• Understanding social cognition deficits in individuals at high risk for schizophrenia

  This study is looking at how people who are at risk of developing schizophrenia understand social situations, like reading facial expressions or following conversations, by watching movie clips and listening to stories, to find ways to help them improve their social skills.

  NIH research New York State Psychiatric Institute Dba Research Foundation for Mental Hygiene, INC · New York, United States · NIH-10459498

• Understanding social interaction challenges in youth with autism and schizophrenia

  This study is looking at how the brains of young people with autism and schizophrenia work when it comes to social interactions, hoping to find ways to help them improve their social skills and experiences.

  NIH research Loma Linda University · Loma Linda, UNITED STATES · NIH-10442538

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.