Effects of a medication on blood vessel stiffness in veterans with obesity
Official title: Arterial Destiffening Effects of SGLT2 Inhibition in Veterans with Obesity
Funded at Harry S. Truman Memorial VA Hospital · NIH-11047997 · Data updated 2026-11-12
This study is looking at how a certain medication might help make blood vessels more flexible in veterans with obesity, which can help lower their risk of heart problems.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Harry S. Truman Memorial VA Hospital NIH-funded |
| Lab location | 1 site (Columbia, United States) |
| Project start | April 1, 2025 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| NIH project number | 1I01CX002859-01 |
| Project ID | NIH-11047997 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are veterans who are obese and at risk for cardiovascular disease.
✕Less likely to help
Patients who are not veterans or do not have obesity-related cardiovascular issues may not benefit from this research.
What this research studies
This research investigates how a specific medication can reduce arterial stiffness in veterans suffering from obesity, a condition that significantly increases the risk of cardiovascular disease. The study aims to understand the underlying mechanisms of arterial stiffening and how they can be targeted for treatment. By focusing on the role of vascular smooth muscle cells and the extracellular matrix, the research seeks to identify effective therapeutic strategies to improve cardiovascular health in this population. Participants may undergo assessments to evaluate their arterial health and response to the treatment.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve cardiovascular health and reduce the risk of heart disease in veterans with obesity.
How similar studies have gone: Previous research has shown promising results in targeting arterial stiffness, indicating that this approach may lead to significant advancements in treatment.
Where this research is happening
-
Harry S. Truman Memorial VA Hospital
Columbia, United States Active
Researchers
- Principal investigator: Padilla, Jaume — Harry S. Truman Memorial VA Hospital
- Study coordinator: Padilla, Jaume
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.