Effects of a medication on blood vessel stiffness in veterans with obesity
Arterial Destiffening Effects of SGLT2 Inhibition in Veterans with Obesity
This study is looking at how a certain medication might help make blood vessels more flexible in veterans with obesity, which can help lower their risk of heart problems.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Harry S. Truman Memorial VA Hospital NIH-funded |
| Lab location | 1 site (Columbia, United States) |
| Project ID | NIH-11047997 on NIH RePORTER |
What this research studies
This research investigates how a specific medication can reduce arterial stiffness in veterans suffering from obesity, a condition that significantly increases the risk of cardiovascular disease. The study aims to understand the underlying mechanisms of arterial stiffening and how they can be targeted for treatment. By focusing on the role of vascular smooth muscle cells and the extracellular matrix, the research seeks to identify effective therapeutic strategies to improve cardiovascular health in this population. Participants may undergo assessments to evaluate their arterial health and response to the treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are veterans who are obese and at risk for cardiovascular disease.
Not a fit: Patients who are not veterans or do not have obesity-related cardiovascular issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve cardiovascular health and reduce the risk of heart disease in veterans with obesity.
How similar studies have performed: Previous research has shown promising results in targeting arterial stiffness, indicating that this approach may lead to significant advancements in treatment.
Where this research is happening
Columbia, United States
- Harry S. Truman Memorial VA Hospital — Columbia, United States (Active)
Researchers
- Principal investigator: Padilla, Jaume — Harry S. Truman Memorial VA Hospital
- Study coordinator: Padilla, Jaume
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.