Effects of a high-fat diet on brain blood flow in people with a specific gene
APOE genotype effects on triglycerides and blood flow in the human brain
This study is looking at how older adults with the APOE ε4 gene, which is connected to Alzheimer's disease, react to a high-fat drink by checking changes in blood flow to the brain, to help us understand how diet might affect brain health and thinking skills.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10795866 on NIH RePORTER |
What this research studies
This research investigates how individuals with the APOE ε4 gene, which is linked to Alzheimer's disease, respond to a high-fat diet in terms of brain blood flow and metabolism. Participants will consume a high-fat drink, and researchers will use non-invasive MRI techniques to measure changes in cerebral blood flow. The study aims to understand the relationship between blood flow, cognitive function, and metabolic responses in older adults, particularly focusing on those with the APOE ε4 gene. Additionally, it will explore how metabolic factors like glucose tolerance may influence these responses.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults who carry the APOE ε4 gene and are interested in understanding their metabolic responses to dietary changes.
Not a fit: Patients who do not carry the APOE ε4 gene or are not older adults may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and management of Alzheimer's disease risk in individuals with the APOE ε4 gene.
How similar studies have performed: Previous research has shown promising results in understanding the effects of diet on brain function, particularly in populations at risk for Alzheimer's disease, suggesting that this approach may yield valuable insights.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Hanson, Angela Jean — University of Washington
- Study coordinator: Hanson, Angela Jean
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.