Effectiveness of discounted antibiotics against resistant bacterial infections
Surprising Efficacy of Discounted Antibiotics vs. MDR Gram-Negative Pathogens Occurring Through Innate Immune Sensitization
This study is looking at how the antibiotic azithromycin can help boost your immune system to better fight tough infections caused by bacteria that are hard to treat, like Klebsiella pneumoniae, so we can find new ways to help people who have limited treatment options.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10665716 on NIH RePORTER |
What this research studies
This research investigates how certain antibiotics, particularly azithromycin, can enhance the body's innate immune response against multi-drug resistant bacteria like Klebsiella pneumoniae and others. The study challenges traditional testing methods that do not consider the immune system's role in fighting infections. By understanding how antibiotics can work in synergy with the immune system, the research aims to find new treatment strategies for serious infections that currently have limited options.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with infections caused by multi-drug resistant Gram-negative bacteria.
Not a fit: Patients with infections caused by non-resistant bacteria or those who do not respond to antibiotic treatments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients suffering from infections caused by antibiotic-resistant bacteria.
How similar studies have performed: Other research has shown promising results in enhancing antibiotic efficacy through immune system interactions, suggesting potential for success in this approach.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Nizet, Victor — University of California, San Diego
- Study coordinator: Nizet, Victor
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.