Editing genes linked to age-related vision loss
Official title: Editing AMD Risk Alleles in Human Cells
Funded at University of Iowa · NIH-11037617 · Data updated 2026-11-12
This study is looking at how we can use new gene-editing methods to change certain genes that increase the risk of age-related macular degeneration (AMD), with the hope of slowing down or preventing vision loss for people affected by this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Iowa NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project start | April 1, 2025 |
| Project end | March 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $620,149 |
| NIH project number | 1R01EY036994-01 |
| Project ID | NIH-11037617 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with genetic predispositions to age-related macular degeneration, particularly those with high-risk genotypes.
✕Less likely to help
Patients who do not have genetic risk factors for age-related macular degeneration may not benefit from this research.
What this research studies
This research focuses on age-related macular degeneration (AMD), a leading cause of vision loss. It aims to use advanced genome editing techniques to modify specific genetic risk factors associated with AMD in human cells. By targeting the genes responsible for AMD, the research seeks to prevent or slow down the progression of the disease, potentially offering a new approach to treatment. The study will involve collaboration among experts in various fields to ensure effective editing of these risk alleles in retinal cells.
Why it matters
Potential benefit: If successful, this research could lead to new preventative treatments for age-related macular degeneration, significantly improving vision preservation for at-risk individuals.
How similar studies have gone: Other research has shown promise in using genome editing techniques for similar genetic conditions, indicating potential for success in this novel approach.
Where this research is happening
-
University of Iowa
Iowa City, United States Active
Researchers
- Principal investigator: Mullins, Robert Foster — University of Iowa
- Study coordinator: Mullins, Robert Foster
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.