Editing genes in patient-derived stem cells to study lung diseases
Official title: iPSC Gene Editing Core
Funded at Boston University Medical Campus · NIH-11046605 · Data updated 2026-11-12
This study is working on using advanced gene editing to fix genetic issues in stem cells from patients with lung diseases, helping researchers learn more about these conditions and develop better treatments.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University Medical Campus NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | March 1, 2024 |
| Project end | February 28, 2029 |
| Funding year | 2025 |
| Award (this year) | $427,602 |
| NIH project number | 5P01HL170952-02 |
| Project ID | NIH-11046605 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with genetic lung diseases who can provide iPSC samples.
✕Less likely to help
Patients without genetic lung diseases or those who do not wish to participate in stem cell research may not benefit from this research.
What this research studies
This research focuses on developing a core laboratory that utilizes advanced gene editing techniques on induced pluripotent stem cells (iPSCs) derived from patients with genetic lung diseases. The project aims to correct genetic variants associated with these diseases and create models that can help researchers understand the conditions better. By generating and biobanking edited iPSC lines, the research will facilitate a wide range of experiments across multiple genetic backgrounds. The core will also produce lentiviral constructs that are essential for various projects within the program.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential treatments for genetic lung diseases.
How similar studies have gone: Previous research using CRISPR technology for gene editing in stem cells has shown promising results, indicating a strong potential for success in this approach.
Where this research is happening
-
Boston University Medical Campus
Boston, United States Active
Researchers
- Principal investigator: Wilson, Andrew a — Boston University Medical Campus
- Study coordinator: Wilson, Andrew a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.