Editing genes in bladder tissue to improve understanding of bladder diseases
Official title: Intravesical genome editing in urothelium
Funded at New York University School of Medicine · NIH-10863056 · Data updated 2026-11-12
This study is looking at new ways to change genes in the bladder lining to learn more about bladder diseases and find better treatments, using a common procedure to reach the tissue in live mice.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | August 16, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $207,000 |
| NIH project number | 1R21DK139437-01 |
| Project ID | NIH-10863056 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old who may be affected by bladder-related conditions.
✕Less likely to help
Patients with conditions unrelated to bladder diseases or those under 21 years old may not benefit from this research.
What this research studies
This research aims to explore new methods for editing genes in the urothelium, the tissue lining the bladder, using advanced techniques like CRISPR. By performing these edits in live mice, the researchers hope to better understand how bladder diseases develop and how they can be treated. The approach involves using transurethral catheterization, a common medical procedure, to access the urothelium easily. This study seeks to overcome current limitations in urothelial research by developing more efficient and cost-effective methods for gene editing.
Why it matters
Potential benefit: If successful, this research could lead to significant advancements in the treatment and understanding of bladder diseases.
How similar studies have gone: Previous research using gene editing technologies like CRISPR has shown promise in other areas, suggesting potential success in this novel application.
Where this research is happening
-
New York University School of Medicine
New York, United States Active
Researchers
- Principal investigator: Wu, Xue-Ru — New York University School of Medicine
- Study coordinator: Wu, Xue-Ru
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.