Editing genes in bladder tissue to improve understanding of bladder diseases
Intravesical genome editing in urothelium
This study is looking at new ways to change genes in the bladder lining to learn more about bladder diseases and find better treatments, using a common procedure to reach the tissue in live mice.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10863056 on NIH RePORTER |
What this research studies
This research aims to explore new methods for editing genes in the urothelium, the tissue lining the bladder, using advanced techniques like CRISPR. By performing these edits in live mice, the researchers hope to better understand how bladder diseases develop and how they can be treated. The approach involves using transurethral catheterization, a common medical procedure, to access the urothelium easily. This study seeks to overcome current limitations in urothelial research by developing more efficient and cost-effective methods for gene editing.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who may be affected by bladder-related conditions.
Not a fit: Patients with conditions unrelated to bladder diseases or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to significant advancements in the treatment and understanding of bladder diseases.
How similar studies have performed: Previous research using gene editing technologies like CRISPR has shown promise in other areas, suggesting potential success in this novel application.
Where this research is happening
New York, United States
- New York University School of Medicine — New York, United States (Active)
Researchers
- Principal investigator: Wu, Xue-Ru — New York University School of Medicine
- Study coordinator: Wu, Xue-Ru
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.