Editing Cancer Genes for New Drug Discoveries
Base-Editing the Cancer Kinome to Enable Drug Discovery
['FUNDING_OTHER'] · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · NIH-11320414
This project is finding new ways to turn off specific genes in cancer cells to help discover better treatments for patients.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NEW YORK UNIVERSITY SCHOOL OF MEDICINE (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11320414 on ClinicalTrials.gov |
What this research studies
Cancer cells often grow too much because certain enzymes called kinases are not working correctly. This project uses a new method called base editing to precisely turn off these enzymes in cancer cells. By doing this, researchers can learn which specific kinases are most important for cancer growth. This knowledge will help identify new targets for developing more effective cancer medications.
Who could benefit from this research
Good fit: This foundational work is not directly recruiting patients but aims to benefit those with various cancers by identifying new therapeutic strategies.
Not a fit: Patients seeking immediate treatment options would not directly benefit from this early-stage laboratory research.
Why it matters
Potential benefit: If successful, this work could lead to the discovery of entirely new drug targets and combinations for many types of cancer, offering more effective treatment options.
How similar studies have performed: While previous methods have tried to turn off genes, this base-editing approach is a novel and more precise way to mimic drug effects, making it a new frontier in drug discovery.
Where this research is happening
NEW YORK, UNITED STATES
- NEW YORK UNIVERSITY SCHOOL OF MEDICINE — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: VASAN, NEIL — NEW YORK UNIVERSITY SCHOOL OF MEDICINE
- Study coordinator: VASAN, NEIL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.