Eating Disorders Genetics Initiative 2 (EDGI2) to understand and improve care for people with eating disorders
Official title: 3/3 Eating Disorders Genetics Initiative 2 (EDGI2)
Funded at Karolinska Institute · NIH-11303319 · Data updated 2026-11-12
A large international study to find genetic factors linked to eating disorders, with the goal of informing better diagnosis and treatment for people affected by these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Karolinska Institute NIH-funded |
| Lab location | 1 site (Solna, Sweden) |
| Project start | May 6, 2024 |
| Project end | February 28, 2029 |
| Funding year | 2026 |
| Award (this year) | $551,835 |
| NIH project number | 5R01MH136156-03 |
| Project ID | NIH-11303319 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals with anorexia nervosa, bulimia nervosa, binge-eating disorder, ARFID, or related controls who participate in the online assessments and provide biosamples.
✕Less likely to help
Individuals without a diagnosed eating disorder or who do not participate in genetic research may not benefit directly.
What this research studies
EDGI2 is a collaborative effort to enroll about 20,000 new participants worldwide, including those with anorexia nervosa, bulimia nervosa, binge-eating disorder, ARFID, and controls, using a harmonized online assessment and biosample collection. The project will perform comprehensive genomic analyses to identify common and rare genetic factors and understand how these factors relate to different subgroups and traits. By integrating genetic data with clinical and environmental information, EDGI2 aims to clarify causal pathways and identify potential targets for precision approaches to care. The findings could help clinicians predict risk, tailor interventions, and guide future therapies for eating disorders.
Why it matters
Potential benefit: Could lead to more accurate risk prediction and personalized treatments for people with eating disorders.
How similar studies have gone: Previous EDGI studies and related efforts have generated meaningful genetic insights and informed subsequent research directions.
Where this research is happening
-
Karolinska Institute
Solna, Sweden Active
Researchers
- Principal investigator: Yi, Lu — Karolinska Institute
- Study coordinator: Yi, Lu
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.