Easier penicillin allergy checks before outpatient surgery, transplant, and pregnancy care
Adapting and Implementing Risk-Stratified Penicillin Allergy Evaluation in Key Outpatient Settings
This project helps people with a penicillin allergy label use a short self-questionnaire and clinic steps so low-risk patients can safely get penicillin before surgeries, transplants, or childbirth.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-11193520 on NIH RePORTER |
What this research studies
You may be asked to complete a brief questionnaire about any past reactions to penicillin and related antibiotics. Clinicians will use a proven, risk-based process to identify people who are unlikely to be truly allergic. Low-risk patients might be given a supervised single-dose challenge or have the allergy label removed by non-allergy clinicians in outpatient settings. The team will adapt and pilot these procedures across pre-surgical, transplant, and obstetric clinics to make delabeling easier and more widely available.
Who could benefit from this research
Good fit: People who carry a penicillin allergy label and are scheduled for outpatient surgery, transplant evaluation, or obstetric care are the ideal candidates.
Not a fit: People with a clear history of severe immediate allergic reactions (for example, prior anaphylaxis) or those needing urgent inpatient antibiotics may not benefit from this outpatient approach.
Why it matters
Potential benefit: If successful, more people will be able to safely receive first-line penicillin antibiotics, lowering treatment failures, drug resistance, and opportunistic infections.
How similar studies have performed: Earlier work by the investigators showed high accuracy (about 99% NPV) using risk-stratified delabeling with over 400 patients removed from allergy lists, and this project expands that approach to new outpatient settings.
Where this research is happening
Nashville, United States
- Vanderbilt University Medical Center — Nashville, United States (Active)
Researchers
- Principal investigator: Stone, Cosby a — Vanderbilt University Medical Center
- Study coordinator: Stone, Cosby a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.