Early changes in pancreatic precancerous lesions (PanIN)
TBEL Project 3
['FUNDING_OTHER'] · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · NIH-11173907
This project uses 3-D imaging and genetic testing of pancreatic precancer tissue to find what makes some PanIN lesions turn into cancer so people at risk might be caught earlier.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NEW YORK UNIVERSITY SCHOOL OF MEDICINE (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11173907 on ClinicalTrials.gov |
What this research studies
From a patient's view, researchers will work with real pancreatic precursor tissue (PanIN) to map how abnormal cells grow and change. They will reconstruct the tissue in three dimensions and take samples from multiple regions to do whole-exome genetic sequencing and trace how cell clones expand. At the same time they will study nearby immune and stromal (support) cells in the same samples to look for non-genetic signals that drive progression. Combining 3-D anatomy, genetics, and the local microenvironment aims to show why some PanINs become high-grade and others do not.
Who could benefit from this research
Good fit: Ideal candidates would be people who have pancreatic precursor lesions (PanIN) identified during surgery or biopsy, or those undergoing care at centers that collect pancreatic tissue for research.
Not a fit: People without PanIN lesions or those with already advanced, invasive pancreatic cancer are unlikely to benefit directly from this project.
Why it matters
Potential benefit: If successful, this work could help identify which precancerous pancreatic lesions are likely to progress and enable earlier detection or prevention efforts.
How similar studies have performed: Prior studies have found genetic changes in some PanINs, but combining multi-region sequencing with 3-D reconstruction and matched immune/stromal analysis is a relatively new and more comprehensive approach.
Where this research is happening
NEW YORK, UNITED STATES
- NEW YORK UNIVERSITY SCHOOL OF MEDICINE — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WOOD, LAURA DELONG — NEW YORK UNIVERSITY SCHOOL OF MEDICINE
- Study coordinator: WOOD, LAURA DELONG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancer Cause, Cancer Etiology