E-cigarette harm-reduction option for cancer outpatients who decline standard tobacco treatment

A Novel Harm Reduction Approach for Oncology Outpatients who Smoke and Refuse Traditional Tobacco Treatment

NIH-funded research Medical University of South Carolina · NIH-11239027

This project offers e-cigarettes to cancer outpatients who smoke and refuse usual quit programs to help them switch from cigarettes and lower exposure to harmful chemicals.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionMedical University of South Carolina NIH-funded
Lab location1 site (Charleston, United States)
Project IDNIH-11239027 on NIH RePORTER

What this research studies

If you are a cancer outpatient who smokes and has declined standard tobacco treatment, you could be invited to join this trial. Participants will be randomly assigned to receive an e-cigarette switching approach or the usual care resources offered by the clinic. The team will track who switches from cigarettes to e-cigarettes, measure markers of smoke exposure, and study what makes this approach easier or harder to use in cancer care. The goal is to find a practical harm-reduction option for patients who will not engage with traditional quitting treatments.

Who could benefit from this research

Good fit: Adult oncology outpatients who currently smoke cigarettes and explicitly refuse all components of standard tobacco treatment are the intended participants.

Not a fit: Patients who already accept traditional tobacco treatment, who cannot or choose not to use e-cigarettes, or who continue smoking without switching are unlikely to gain benefit from this approach.

Why it matters

Potential benefit: If successful, this approach could reduce patients' exposure to cigarette-related carcinogens and lower smoking-related harms for those who refuse standard quitting programs.

How similar studies have performed: Prior research indicates switching from cigarettes to e-cigarettes can lower exposure to many harmful chemicals, but long-term benefits and effectiveness specifically in cancer patients are still uncertain.

Where this research is happening

Charleston, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions Cancer BurdenCancer Causing AgentsCancer CenterCancer PatientCancers
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.