Durablate catheter treatment for ventricular tachycardia
Eliminating Ventricular Tachycardia: Pivotal Clinical Trial using the Durablate® Catheter
A new catheter that delivers heated saline plus radiofrequency energy aims to remove the heart tissue causing ventricular tachycardia in people who have VT and receive ICD shocks.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Thermedical, INC. NIH-funded |
| Lab location | 1 site (Waltham, United States) |
| Project ID | NIH-11175368 on NIH RePORTER |
What this research studies
If you join, doctors will use 3-D CT or MRI images merged with electroanatomic maps to pinpoint the heart tissue causing VT. They will then use the Durablate® catheter to deliver heated saline together with radiofrequency energy to reach and destroy deep arrhythmia-causing tissue. The trial is a pivotal clinical device trial led by the device developer and will be offered at participating hospitals that perform complex ablations. You will have follow-up visits to monitor heart rhythm, symptoms, and safety after the procedure.
Who could benefit from this research
Good fit: Adults with recurrent ventricular tachycardia, especially those with ICDs or who are candidates for catheter ablation, are the most likely candidates for this trial.
Not a fit: People whose arrhythmias are not ventricular in origin, who are not eligible for catheter ablation, or whose heart anatomy prevents safe catheter access are unlikely to benefit.
Why it matters
Potential benefit: If successful, this approach could reduce or eliminate painful ICD shocks and potentially reduce the need for ICD implants, improving quality of life and lowering costs.
How similar studies have performed: Catheter ablation is established for atrial arrhythmias and used in some VT cases, but this heated-saline plus RF approach is relatively new and less widely tested for treating deep VT substrates.
Where this research is happening
Waltham, United States
- Thermedical, INC. — Waltham, United States (Active)
Researchers
- Principal investigator: Curley, Michael G — Thermedical, INC.
- Study coordinator: Curley, Michael G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.