Drug to help nerve regrowth after spinal cord injury
Developing a kinase inhibitor drug to treat spinal cord injury
['FUNDING_OTHER'] · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · NIH-11301811
A new drug that aims to help damaged spinal cord nerves regrow in adults with spinal cord injury.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MIAMI SCHOOL OF MEDICINE (nih funded) |
| Locations | 1 site (CORAL GABLES, UNITED STATES) |
| Trial ID | NIH-11301811 on ClinicalTrials.gov |
What this research studies
Researchers are developing a small-molecule drug designed to encourage nerve fibers in the spinal cord to regrow after injury. They discovered the compound using lab screening, target profiling, and machine-learning to find a molecule that can both boost neurons' own growth and reduce blocking signals around the injury. Current work includes laboratory tests and animal models to check safety and effect before any human testing. The long-term goal is to move this approach into human trials so people with spinal cord injury might gain improved function.
Who could benefit from this research
Good fit: Ideal candidates would be adults living with spinal cord injury who are willing to enroll in early-phase drug trials when they become available.
Not a fit: People with medical conditions that make them ineligible for drug trials, certain types of injuries that cannot be repaired, or those who cannot travel to trial sites may not benefit from this research.
Why it matters
Potential benefit: If successful, the drug could help re-establish nerve connections and improve movement, bladder control, and daily function after spinal cord injury.
How similar studies have performed: There are currently no approved drugs that promote axon regeneration after spinal cord injury, and this compound is novel because it targets both intrinsic neuronal growth and extrinsic inhibitory signals, so it is promising but not yet tested in humans.
Where this research is happening
CORAL GABLES, UNITED STATES
- UNIVERSITY OF MIAMI SCHOOL OF MEDICINE — CORAL GABLES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: AL ALI, HASSAN — UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
- Study coordinator: AL ALI, HASSAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.