Drug interactions and fall risk for nursing home residents with dementia
Clinically Significant Drug Interactions among Nursing Home Residents with ADRD
This project will identify harmful drug combinations that increase fall risk in nursing home residents with Alzheimer's disease and related dementias.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brown University NIH-funded |
| Lab location | 1 site (Providence, United States) |
| Project ID | NIH-11090409 on NIH RePORTER |
What this research studies
If you or a loved one live in a nursing home with dementia, researchers will examine medication lists and health records to find which drug combinations are linked to falls and related injuries. The team will use large nursing-home datasets and novel screening tools to flag likely interactions, then apply rigorous causal inference methods to test which ones actually increase risk. The goal is to validate clinically important interactions rather than rely on theoretical warnings alone. Findings will be shared with clinicians to help avoid dangerous medication combinations for residents with ADRD.
Who could benefit from this research
Good fit: Ideal candidates are nursing home residents diagnosed with Alzheimer's disease or a related dementia who are taking multiple medications or have a history of falls.
Not a fit: People without dementia or those who do not live in nursing homes are unlikely to directly benefit from this specific project.
Why it matters
Potential benefit: If successful, this work could help clinicians avoid dangerous drug combinations and reduce fall-related injuries among nursing home residents with dementia.
How similar studies have performed: Some prior medication-safety research and reviews suggest certain drug combinations raise fall risk, but comprehensive, validated evidence specific to nursing home residents with dementia is limited.
Where this research is happening
Providence, United States
- Brown University — Providence, United States (Active)
Researchers
- Principal investigator: Zullo, Andrew Reis — Brown University
- Study coordinator: Zullo, Andrew Reis
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.