Drug-Induced Liver Injury Center at UNC
University of North Carolina Clinical Center for DILIN
This center follows people who may have liver damage from medicines to help improve how we spot, prevent, and treat it.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project ID | NIH-11170615 on NIH RePORTER |
What this research studies
I can join a program that enrolls people with suspected medication-related liver injury and collects medical records, blood tests, and sometimes liver tissue samples. The center leads many studies and works with other groups to look for genetic risk scores and new blood-based biomarkers. They are expanding outreach through community clinics and partnerships with a historically Black university to include more minority patients. The team runs pilot studies and lab collaborations to learn why certain drugs harm the liver and how to stop it.
Who could benefit from this research
Good fit: Ideal candidates are people who have or recently had abnormal liver tests suspected to be caused by a prescription drug, over-the-counter medicine, or herbal supplement.
Not a fit: People whose liver disease is clearly due to chronic non-drug causes or who cannot access participating sites may not gain direct benefit from joining.
Why it matters
Potential benefit: If successful, this work could produce tests to identify people at higher risk and new ways to prevent or treat drug-related liver injury.
How similar studies have performed: Previous DILIN work has already found genetic risk factors and promising biomarkers, so this effort builds on established findings.
Where this research is happening
Chapel Hill, United States
- Univ of North Carolina Chapel Hill — Chapel Hill, United States (Active)
Researchers
- Principal investigator: Watkins, Paul B — Univ of North Carolina Chapel Hill
- Study coordinator: Watkins, Paul B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.