Drivers of cell division errors in clear cell kidney cancer
Convergent Drivers of Tumor Evolution at the Mitotic Spindle
['FUNDING_R01'] · VANDERBILT UNIVERSITY MEDICAL CENTER · NIH-11118671
Researchers are looking at how common gene changes in clear cell kidney cancer cause cells to divide incorrectly and where that may reveal new treatment targets.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VANDERBILT UNIVERSITY MEDICAL CENTER (nih funded) |
| Locations | 1 site (NASHVILLE, UNITED STATES) |
| Trial ID | NIH-11118671 on ClinicalTrials.gov |
What this research studies
This work examines gene changes that almost always happen in clear cell kidney cancer and how those changes make tumor cells mess up when they divide. Scientists are following how proteins from those altered genes interact with the cell's division machinery (the mitotic spindle) using laboratory models and tumor samples. The team uses genetic tools and molecular experiments to pinpoint which changes lead to unstable DNA and faster tumor evolution. Understanding these mechanisms could highlight specific weak points in the cancer that future therapies might target.
Who could benefit from this research
Good fit: People with clear cell renal cell carcinoma, especially those whose tumors have the chromosome changes (loss of 3p and gain of 5q) or who can donate tumor samples, would be most relevant to this research.
Not a fit: Patients with other types of kidney cancer or those unable to provide tissue samples are less likely to directly benefit from this specific work.
Why it matters
Potential benefit: If successful, the project could reveal new molecular targets to stop or slow tumor growth in clear cell kidney cancer.
How similar studies have performed: Previous laboratory studies have linked the same genes (like SETD2, PBRM1, and VHL) to cell division and genome instability, but translating these findings into treatments is still early and unproven.
Where this research is happening
NASHVILLE, UNITED STATES
- VANDERBILT UNIVERSITY MEDICAL CENTER — NASHVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MASON, FRANK M — VANDERBILT UNIVERSITY MEDICAL CENTER
- Study coordinator: MASON, FRANK M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.