Discovering new genes related to liver and bile duct disorders
Novel gene discovery in disorders of the liver and biliary tree
This study is looking for new genes that might cause liver and bile duct problems in kids, using special techniques to help doctors better understand these conditions and find better ways to diagnose and treat them.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10988237 on NIH RePORTER |
What this research studies
This research focuses on identifying and characterizing new genes that may contribute to liver and biliary diseases, particularly in children. The principal investigator, who is training to become an independent hepatogeneticist, will utilize advanced techniques such as exome sequencing and zebrafish models to explore genetic variants associated with these conditions. The research aims to enhance understanding of the genetic basis of liver disorders, which could lead to improved diagnostic and therapeutic strategies for affected patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are children with known or suspected liver and biliary diseases.
Not a fit: Patients with liver disorders unrelated to genetic factors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better diagnosis and treatment options for children suffering from liver and biliary disorders.
How similar studies have performed: Previous research has shown success in gene discovery for other genetic disorders, indicating potential for similar breakthroughs in hepatobiliary diseases.
Where this research is happening
Philadelphia, United States
- Children's Hosp of Philadelphia — Philadelphia, United States (Active)
Researchers
- Principal investigator: Strong, Alanna — Children's Hosp of Philadelphia
- Study coordinator: Strong, Alanna
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.