Discovering new antibiotic compounds from natural sources
Official title: Bioinformatic Guided Discovery and Characterization of New RiPP Natural Products
Funded at University of North Carolina Greensboro · NIH-11088763 · Data updated 2026-11-12
This study is looking for new natural antibiotics that could help treat infections, using advanced technology to find and understand the organisms that make them, so that patients can have better treatment options in the future.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of North Carolina Greensboro NIH-funded |
| Lab location | 1 site (Greensboro, United States) |
| Project start | August 1, 2022 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $348,202 |
| NIH project number | 5R35GM147439-04 |
| Project ID | NIH-11088763 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include individuals suffering from bacterial infections that are difficult to treat with existing antibiotics.
✕Less likely to help
Patients with viral infections or those who do not have antibiotic-resistant bacterial infections may not receive benefit from this research.
What this research studies
This research focuses on identifying and characterizing new types of natural products that can serve as antibiotics. By using advanced bioinformatics and genome mining techniques, the researchers aim to efficiently discover promising organisms and their genetic blueprints that produce these bioactive compounds. The study will involve detailed biochemical analyses and bioactivity assessments to understand how these natural products can be utilized for human health. Patients may benefit from new antibiotic treatments developed from these discoveries.
Why it matters
Potential benefit: If successful, this research could lead to the development of new antibiotics that are effective against resistant bacterial infections.
How similar studies have gone: Other research has shown success in discovering new antibiotics through similar bioinformatics and genome mining approaches, indicating a promising avenue for future breakthroughs.
Where this research is happening
-
University of North Carolina Greensboro
Greensboro, United States Active
Researchers
- Principal investigator: Chekan, Jonathan Rodi — University of North Carolina Greensboro
- Study coordinator: Chekan, Jonathan Rodi
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.