Discovering new adjuvants to enhance flu vaccine effectiveness
Official title: VACCINE ADJUVANT DISCOVERY PROGRAM (VADP)
Funded at Boston Children's Hospital · NIH-11202903 · Data updated 2026-11-12
This study is looking for new ways to make flu vaccines work better by testing different small compounds that can help strengthen your immune response, using samples from human blood.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 30, 2024 |
| Project end | September 29, 2029 |
| Funding year | 2024 |
| Award (this year) | $1,435,380 |
| NIH project number | 75N93024C00020-0-9999-1 |
| Project ID | NIH-11202903 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include adults and elderly individuals who are receiving flu vaccinations.
✕Less likely to help
Patients who are not receiving flu vaccines or those with contraindications to vaccination may not benefit from this research.
What this research studies
This research focuses on identifying new adjuvants that can boost the immune response to influenza vaccines. By screening a library of small molecules using human blood cells, the team aims to find compounds that can enhance T cell responses. The selected lead molecules will undergo further studies to understand how they work and will be optimized for better performance when combined with flu vaccines. Different formulations and delivery methods will also be evaluated to maximize their effectiveness.
Why it matters
Potential benefit: If successful, this research could lead to more effective flu vaccines that provide better protection against influenza.
How similar studies have gone: Previous research has shown that enhancing vaccine adjuvants can significantly improve immune responses, indicating potential success for this approach.
Where this research is happening
-
Boston Children's Hospital
Boston, United States Active
Researchers
- Principal investigator: Levy, Ofer — Boston Children's Hospital
- Study coordinator: Levy, Ofer
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.