Discovering immune system targets for better disease understanding
Large Scale T Cell Epitope Discovery
This study is looking at how certain parts of germs can help our immune system recognize and fight infections, using human T cells to see how well these parts work, and the findings will be shared to help scientists learn more about how our bodies protect us from diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Massachusetts Med Sch Worcester NIH-funded |
| Lab location | 1 site (Worcester, United States) |
| Project ID | NIH-11179084 on NIH RePORTER |
What this research studies
This research focuses on identifying and validating T cell immune epitopes, which are crucial for understanding how the immune system recognizes and responds to various pathogens. The team will conduct in vitro studies using primary human T cells to test the effectiveness of these epitopes in triggering immune responses. By compiling this information into a database, the research aims to provide valuable resources for the broader scientific community, enhancing our understanding of immune protection and disease mechanisms.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to immune system responses, such as infections caused by specific pathogens like Coccidioides or Histoplasma.
Not a fit: Patients with conditions unrelated to immune responses or those not affected by the targeted pathogens may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tools and therapeutic strategies for diseases linked to immune responses.
How similar studies have performed: Previous research has shown success in identifying immune epitopes, indicating that this approach has the potential for meaningful advancements in understanding immune responses.
Where this research is happening
Worcester, United States
- Univ of Massachusetts Med Sch Worcester — Worcester, United States (Active)
Researchers
- Principal investigator: Gage, Kasia — Univ of Massachusetts Med Sch Worcester
- Study coordinator: Gage, Kasia
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.