Discovering how T cells recognize and protect against certain sexually transmitted infections.
Large-Scale T Cell Immune Epitope Discovery and Mechanisms of T Cell Protection
This study is looking at how our immune system recognizes certain parts of sexually transmitted infections like herpes, syphilis, and chlamydia, by examining blood and tissue samples from people who have these infections, to help improve our understanding of how to fight them off.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-11203530 on NIH RePORTER |
What this research studies
This research focuses on identifying specific T cell epitopes related to sexually transmitted infections, particularly herpes simplex viruses, syphilis, and chlamydia. By analyzing blood and tissue samples from infected individuals, the study aims to validate pairs of microbial peptide epitopes and HLA alleles that are crucial for T cell recognition. The research will also explore T cell receptor complexes that interact with these epitopes, enhancing our understanding of immune responses to these infections.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals infected with herpes simplex virus types 1 or 2, Treponema pallidum, or Chlamydia trachomatis.
Not a fit: Patients who are not infected with the targeted sexually transmitted infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved vaccines or therapies for sexually transmitted infections.
How similar studies have performed: Previous research has shown promise in identifying T cell responses to viral infections, suggesting potential success for this approach.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Koelle, David — University of Washington
- Study coordinator: Koelle, David
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.