Discovering genetic mutation patterns in tumors
Robust, scalable, and accurate discovery of mutational signatures
['FUNDING_R01'] · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · NIH-10665756
This study is looking at how changes in cancer genes can help us understand how things in our environment might lead to cancer, and it's creating easy-to-use computer tools to help researchers find these changes more accurately.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10665756 on ClinicalTrials.gov |
What this research studies
This research focuses on identifying and analyzing mutational signatures in tumor genome sequences, which can reveal insights into how environmental factors contribute to cancer development. The team aims to create new computational algorithms that are efficient and user-friendly, allowing for accurate extraction of these signatures despite the complexities involved. By applying advanced statistical methods and testing on large datasets, the research seeks to enhance our understanding of cancer mutations and their origins.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with various types of cancer who are interested in understanding the genetic factors contributing to their condition.
Not a fit: Patients with non-malignant conditions or those not diagnosed with cancer may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved cancer prevention strategies and personalized treatment options based on genetic mutation patterns.
How similar studies have performed: Previous research has shown promise in using computational methods to analyze genetic mutations, indicating that this approach could yield valuable insights.
Where this research is happening
BOSTON, UNITED STATES
- BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HUGGINS, JONATHAN — BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
- Study coordinator: HUGGINS, JONATHAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers, neoplasm/cancer