Digital therapy for opioid use disorder and related mental health issues

Autonomous Digital CBT Intervention for Opioid Use Disorder in Individuals with Co-Occurring Internalizing Disorders

NIH-funded research University of Minnesota · NIH-10936521

This study is testing a helpful online program designed for people dealing with opioid addiction along with anxiety or depression, teaching them how to handle tough emotions without turning to drugs.

Quick facts

Grant typeNIH-funded research
Study typeNIH-funded research
Funding institutionUniversity of Minnesota NIH-funded
Lab location1 site (Minneapolis, United States)
Project IDNIH-10936521 on NIH RePORTER

What this research studies

This research develops a digital cognitive-behavioral therapy (CBT) program aimed at individuals struggling with opioid use disorder and co-occurring anxiety or depression. The program addresses the vicious cycle of addiction by educating patients on how to manage negative emotions without resorting to drug use. Participants will engage with an autonomous digital platform that delivers the therapy, which has shown effectiveness comparable to traditional therapist-led sessions. The approach focuses on teaching coping skills and promoting understanding of addiction's neuro-behavioral aspects.

Who could benefit from this research

Good fit: Ideal candidates for this research are individuals diagnosed with opioid use disorder who also experience anxiety or depression.

Not a fit: Patients who do not have opioid use disorder or co-occurring internalizing disorders may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could provide a scalable and effective treatment option for individuals with opioid use disorder and related mental health conditions.

How similar studies have performed: Previous research has shown success with digital CBT interventions for addiction, indicating promise for this novel application.

Where this research is happening

Minneapolis, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.