Different types of hunger-control brain cells (AgRP neurons)
Identifying and characterizing molecular and circuitry-based heterogeneity of AgRP neurons.
['FUNDING_R01'] · UNIVERSITY OF WASHINGTON · NIH-11312742
Researchers are mapping different subtypes of AgRP brain cells that control hunger and metabolism to help people with eating or weight problems.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF WASHINGTON (nih funded) |
| Locations | 1 site (SEATTLE, UNITED STATES) |
| Trial ID | NIH-11312742 on ClinicalTrials.gov |
What this research studies
The team will use single-cell gene profiling and RNAScope to identify distinct groups of AgRP neurons in the hypothalamus. Experiments in lab models and tissue will test how these subtypes respond to signals such as leptin, glucose, fasting, and cold exposure. They will trace where each subgroup sends signals in the brain to link specific circuits to feeding versus energy use. The goal is to connect molecular signatures with circuit function so future therapies can target the most relevant cells.
Who could benefit from this research
Good fit: People with obesity, overeating, or appetite-related disorders who are interested in future brain-based therapies are the most likely to benefit down the line.
Not a fit: Patients seeking immediate treatment or clinical care should not expect direct benefit because this is basic laboratory research rather than a clinical trial.
Why it matters
Potential benefit: If successful, this work could point to more precise targets for future treatments of obesity and appetite disorders.
How similar studies have performed: Prior animal and single-cell studies have already shown AgRP neuron diversity and links to feeding behavior, but translating those findings into human treatments remains at an early stage.
Where this research is happening
SEATTLE, UNITED STATES
- UNIVERSITY OF WASHINGTON — SEATTLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MORTON, GREGORY J — UNIVERSITY OF WASHINGTON
- Study coordinator: MORTON, GREGORY J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.