Differences in immune cell behavior in asthma between men and women
Official title: Migration and signaling in ILC2 in asthma: Male and female differences
Funded at VA Salt Lake City Healthcare System · NIH-11213834 · Data updated 2026-11-12
This study is looking at how certain immune cells act differently in men and women with asthma, especially focusing on how sex hormones might affect asthma severity, to help find better treatments for women Veterans who often experience more severe asthma symptoms.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA Salt Lake City Healthcare System NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project start | October 1, 2019 |
| Project end | September 30, 2025 |
| Funding year | 2025 |
| NIH project number | 5IK2BX004219-06 |
| Project ID | NIH-11213834 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adult female Veterans diagnosed with asthma.
✕Less likely to help
Patients who are male or do not have a diagnosis of asthma may not receive benefit from this research.
What this research studies
This research investigates how group 2 innate lymphoid cells (ILC2) behave differently in men and women with asthma. It aims to understand the role of sex hormones in asthma severity and how these differences may contribute to the higher prevalence of severe asthma in adult female Veterans. By examining the migration and signaling of these immune cells, the study seeks to uncover potential targets for more effective treatments tailored to each sex. Patients may be involved in clinical assessments to better understand their asthma symptoms and responses to allergens.
Why it matters
Potential benefit: If successful, this research could lead to improved asthma treatments that are more effective for women, potentially reducing the severity and frequency of asthma attacks.
How similar studies have gone: Previous research has indicated that understanding sex differences in immune responses can lead to significant advancements in treatment strategies for asthma, suggesting this approach has potential for success.
Where this research is happening
-
VA Salt Lake City Healthcare System
Salt Lake City, United States Active
Researchers
- Principal investigator: Warren, Kristi J — VA Salt Lake City Healthcare System
- Study coordinator: Warren, Kristi J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.