Differences in how male and female intestines respond to radiation
Official title: Sex specific differences in intestinal radiosensitivity
Funded at University of Kansas Medical Center · NIH-11098596 · Data updated 2026-11-12
This study is looking at how men and women's intestines respond differently to radiation, especially when it comes to gut problems caused by radiation exposure, and it hopes to find ways to help the intestines heal better after such exposure.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kansas Medical Center NIH-funded |
| Lab location | 1 site (Kansas City, United States) |
| Project start | June 1, 2024 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $528,039 |
| NIH project number | 5U01AI183950-02 |
| Project ID | NIH-11098596 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have been exposed to radiation or are at risk of radiation exposure, particularly those over 21 years old.
✕Less likely to help
Patients who have not been exposed to radiation or are not at risk of radiation exposure may not benefit from this research.
What this research studies
This research investigates how male and female intestines react differently to radiation exposure, particularly in the context of gastrointestinal acute radiation syndrome (GI-ARS). It focuses on understanding the mechanisms behind these differences, especially the role of mitochondrial function and oxidative stress in intestinal damage and recovery. By studying the intestinal epithelium, which is highly sensitive to radiation, the research aims to identify potential strategies to improve recovery and mitigate radiation-induced harm. The findings could lead to better treatments and countermeasures for individuals exposed to radiation.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies for patients suffering from radiation exposure, enhancing recovery and reducing complications.
How similar studies have gone: While the specific focus on sex differences in intestinal radiosensitivity is relatively novel, previous research has shown success in understanding radiation effects on intestinal tissues.
Where this research is happening
-
University of Kansas Medical Center
Kansas City, United States Active
Researchers
- Principal investigator: Saha, Subhrajit — University of Kansas Medical Center
- Study coordinator: Saha, Subhrajit
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.