Differences in how male and female eye cells respond to allergens
Official title: Sex difference in conjunctival epithelial cell response and their profile of extracellular bioactive lipids duringallergic inflammation
Funded at Schepens Eye Research Institute · NIH-10914659 · Data updated 2026-11-12
This study is looking at how the cells in your eyes react to allergens differently in men and women, especially focusing on certain substances they release during allergic reactions, to help find better treatments for allergic eye issues.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Schepens Eye Research Institute NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $76,756 |
| NIH project number | 5F32EY035529-02 |
| Project ID | NIH-10914659 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals experiencing allergic eye conditions, particularly those with a history of allergic rhinitis or conjunctival inflammation.
✕Less likely to help
Patients who do not have allergic eye conditions or those with non-allergic ocular issues may not benefit from this research.
What this research studies
This research investigates how conjunctival epithelial cells, which line the inside of the eyelids and cover the eye, respond differently to allergens based on sex. It focuses on the secretion of bioactive lipids during allergic inflammation, particularly looking at how these responses vary between males and females. The study aims to understand the role of specialized lipid mediators in maintaining eye health and how their secretion changes during allergic reactions. By analyzing these differences, the research hopes to uncover new insights into the treatment of allergic eye conditions.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for allergic eye conditions by tailoring therapies based on sex differences.
How similar studies have gone: Other research has shown promising results in understanding sex differences in immune responses, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Schepens Eye Research Institute
Boston, United States Active
Researchers
- Principal investigator: Lee, Changrim — Schepens Eye Research Institute
- Study coordinator: Lee, Changrim
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.