Differences in gut bacteria between African Americans and Non-Hispanic Whites with polyps
Official title: Archaea in African Americans with polyps
Funded at University of Illinois at Chicago · NIH-10753564 · Data updated 2026-11-12
This study is looking at the differences in certain gut bacteria between African Americans and Non-Hispanic Whites who have polyps, which can lead to colorectal cancer, to better understand how these differences might affect cancer risk.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Illinois at Chicago NIH-funded |
| Lab location | 1 site (Chicago, UNITED STATES) |
| Project start | December 12, 2022 |
| Project end | November 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $79,950 |
| NIH project number | 5R03CA277166-02 |
| Project ID | NIH-10753564 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are African Americans with or without polyps, as well as Non-Hispanic Whites with or without polyps.
✕Less likely to help
Patients who do not have polyps or are not of African American or Non-Hispanic White descent may not benefit from this research.
What this research studies
This research investigates the differences in archaea, a type of gut bacteria, between African Americans and Non-Hispanic Whites who have polyps, which are growths that can lead to colorectal cancer. By analyzing existing samples, the study aims to identify variations in the types and functions of these archaea in both groups. The researchers will use advanced techniques like qPCR and metagenomic sequencing to explore these differences and their potential role in colorectal cancer disparities. This study is the first of its kind to focus on the gut microbiome of African Americans in relation to polyps.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing colorectal cancer in African Americans by targeting gut bacteria.
How similar studies have gone: While this research approach is novel in examining archaea in the gut microbiome of African Americans, similar studies have shown promising results in understanding microbiome differences in other populations.
Where this research is happening
-
University of Illinois at Chicago
Chicago, United States Active
Researchers
- Principal investigator: Mutlu, Ece a. — University of Illinois at Chicago
- Study coordinator: Mutlu, Ece a.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.