Diet and its effects on Alzheimer's disease in rabbits
Dietary manipulations in rabbits induce the cellular, neuropathological, and cognitive hallmarks of late-onset Alzheimer's Disease
['FUNDING_OTHER'] · WEST VIRGINIA UNIVERSITY · NIH-10870004
This study is looking at how different diets, like high-fat or high-sugar foods, can cause memory and learning problems in rabbits that are similar to those seen in late-onset Alzheimer's Disease, helping us understand how what we eat might affect brain health.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WEST VIRGINIA UNIVERSITY (nih funded) |
| Locations | 1 site (MORGANTOWN, UNITED STATES) |
| Trial ID | NIH-10870004 on ClinicalTrials.gov |
What this research studies
This research investigates how different dietary patterns can induce symptoms similar to late-onset Alzheimer's Disease (LOAD) in rabbits. By feeding rabbits various diets, including low-dose cholesterol, high-fat, and high-sugar diets, the study aims to replicate the cellular and cognitive changes associated with LOAD. The researchers will assess the impact of these diets on learning and memory through established cognitive tasks, providing insights into how diet influences cognitive decline. This approach seeks to create a more relevant animal model for understanding Alzheimer's disease and its risk factors.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 65 and older who are at risk for or experiencing cognitive decline.
Not a fit: Patients who are younger than 65 or do not have any cognitive impairment may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding of dietary influences on Alzheimer's disease, potentially guiding prevention and treatment strategies for patients.
How similar studies have performed: While there have been studies on dietary impacts on cognitive function, this specific approach using rabbits as a model for Alzheimer's is relatively novel and untested.
Where this research is happening
MORGANTOWN, UNITED STATES
- WEST VIRGINIA UNIVERSITY — MORGANTOWN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SCHREURS, BERNARD G. — WEST VIRGINIA UNIVERSITY
- Study coordinator: SCHREURS, BERNARD G.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Adult-Onset Diabetes Mellitus