Diabetes that can start after acute pancreatitis
Official title: Type 1 Diabetes in Acute Pancreatitis Consortium – Pacific Northwest Clinical Center: Immune Pathogenesis of Post-Pancreatitis T1D
Funded at Benaroya Research Inst at Virginia Mason · NIH-11234743 · Data updated 2026-11-12
This project follows people who had acute pancreatitis to find out how and why diabetes can begin afterward.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Benaroya Research Inst at Virginia Mason NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | September 16, 2020 |
| Project end | July 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $517,100 |
| NIH project number | 2U01DK127404-06 |
| Project ID | NIH-11234743 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are adults recently hospitalized for acute pancreatitis who do not already have established diabetes and are willing to attend follow-up visits and provide blood samples.
✕Less likely to help
People without a history of acute pancreatitis or those with long-standing diabetes unrelated to pancreatic injury are unlikely to benefit directly from this project.
What this research studies
If you recently had acute pancreatitis, researchers will enroll you in a long-term follow-up where they collect health information and blood samples over time. The team will use detailed immune testing and diabetes-related hormone measurements to see which kinds of diabetes develop after pancreatitis. Ten clinical centers in a consortium will enroll participants to get a large, consistent picture of risk factors and timing. The goal is to link immune changes and clinical features to the appearance of diabetes so future detection and care can improve.
Why it matters
Potential benefit: If successful, this work could help identify people at high risk for diabetes after pancreatitis so they can get earlier monitoring and tailored care.
How similar studies have gone: Previous retrospective studies have reported higher diabetes rates after pancreatitis, but large prospective, immune-focused follow-up like this is relatively new.
Where this research is happening
-
Benaroya Research Inst at Virginia Mason
Seattle, United States Active
Researchers
- Principal investigator: Speake, Cate — Benaroya Research Inst at Virginia Mason
- Study coordinator: Speake, Cate
Related research
Other NIH-funded projects on the same topics.
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Continuation of Type 1 Diabetes in Acute Pancreatitis: UF Health and AdventHealth
A patient-facing overview of a long-term study tracking people with acute pancreatitis to understand how some develop type 1 diabetes later and what factors influence that process.
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Data Coordinating Center for Type 1 Diabetes in Acute Pancreatitis Consortium
A national effort to learn how pancreatitis-related Type 1 diabetes develops, by tracking patients and coordinating data to improve future care.
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Type 1 Diabetes in Acute Pancreatitis in Diabetes Patients at Stanford
A Stanford-led project helps people with brittle type 1 diabetes who also experience pancreatitis by following them in a long-term study to understand how acute pancreatitis affects diabetes.
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Type 1 Diabetes after Acute Pancreatitis: Immune Clues from the Pacific Northwest
A multi-center study follows adults after an acute pancreatitis episode to understand how some develop Type 1 diabetes and what immune factors are involved.
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Diabetes After Acute Pancreatitis: Understanding Progression and Genetics at Cedars-Sinai
This grant supports Cedars-Sinai’s clinical center as part of a national effort to study why some adults develop brittle type 1 diabetes after an acute pancreatitis episode and how genes influence this risk.
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Understanding how acute pancreatitis may lead to type 1 diabetes
This study is looking at how having acute pancreatitis might lead to type 1 diabetes, and it aims to find early warning signs and risk factors to help identify people who could be at risk for developing diabetes after pancreatitis.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.