Developmental gene-expression atlas for children and teens
Laboratory, Data Analysis, and Coordinating Center (LDACC) for the Developmental Human Genotype-Tissue Expression Project
['FUNDING_OTHER'] · YALE UNIVERSITY · NIH-11195002
Building a detailed map of how genes are turned on in different tissues, especially the brain, from infancy through adolescence to better understand development.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-11195002 on ClinicalTrials.gov |
What this research studies
This project collects genetic and molecular data from many tissues with a focus on multiple brain regions across four age groups: infancy, early childhood, late childhood, and adolescence. Scientists will measure gene activity in both bulk tissues and individual cell types using genotyping, RNA, and other functional genomic methods. The team will integrate these data to predict how noncoding genetic variants change gene expression and splicing. The project will create a biobank and publicly available atlas that other researchers can use to study child and teen biology.
Who could benefit from this research
Good fit: Families of infants, children, and adolescents who are willing to donate samples (such as blood or tissue) or participate at affiliated collection sites would be ideal candidates to contribute to this effort.
Not a fit: People seeking immediate clinical treatment are unlikely to receive direct benefit because this project builds a research resource rather than offering therapies.
Why it matters
Potential benefit: If successful, the atlas could help explain genetic causes of childhood brain and developmental conditions and guide future diagnostics and treatments.
How similar studies have performed: Large adult atlases like GTEx have been highly useful, but applying similar approaches to postnatal child and adolescent development is novel and less tested.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SESTAN, NENAD — YALE UNIVERSITY
- Study coordinator: SESTAN, NENAD
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.